Maybe you are new to ordering specialty lab testing and looking for a place to start. Or perhaps you are a seasoned clinician interested in learning about the most popular tests your colleagues are using. Regardless, Evexia Diagnostics is dedicated to supporting clinicians in growing their practices and achieving improved patient outcomes. This straightforward guide provides a breakdown of the Top 10 specialty test categories ordered through Evexia Diagnostics and the added insight they can offer you in clinical care.

GI 360

The GI360™ Profile is an innovative, comprehensive and clinically-applicable stool profile, utilizing multiplex PCR molecular technology coupled with growth-based culture and ID by MALDI-TOF, sensitive biochemical assays and microscopy to detect and assess the status of pathogens, viruses, parasites and bacteria that may be contributing to acute or chronic gastrointestinal symptoms and disease.

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GI Effects

The GI Effects Comprehensive Stool Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. This stool analysis utilizes biomarkers such as Calprotectin to differentiate between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome. In addition, the GI Effects test can be used to evaluate patients with a clinical history that suggests a gastrointestinal infection or dysbiosis.

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The GI-MAP (Microbial Assay Plus) is unique in the field of comprehensive stool testing. It relies exclusively on quantitative polymerase chain reaction (qPCR) technology to detect parasites, bacteria, fungi, and more, by targeting the specific DNA of the organisms tested. The GI-MAP™ (GI-Microbial Assay Plus) quantitatively assesses a patient’s microbiome with attention to bacterial, parasitic, and viral pathogens that can cause disease, disrupt the normal microbial balance, and contribute to chronic GI illness.

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The IgE Food Antibody Assessment is a blood test that measures IgE antibodies to 19 of the most allergenic foods. The panel also includes a total IgE measurement. The body can react to foods in many different ways. The prevalence of food allergies in Western countries is rising, with up to 10% of the population affected. This trend likely involves a complex interplay between genetic, epigenetic, and environmental risk factors.1 Testing for IgE food antibodies is useful for individuals who suspect that a food is responsible for causing their symptoms. The presence of circulating antibodies may affect each patient differently. According to the American Academy of Allergy, Asthma, and Immunology, “A key message is that a positive allergy test result (skin or blood) indicates only the presence of allergen-specific IgE (called sensitization). It does not necessarily mean clinical allergy (i.e., allergic symptoms with exposure).”2 Therefore, test results should always be viewed in the context of the overall clinical picture.

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144 Food Sensitivity Panel

Food allergies and sensitivities are recognized to be correlated with many plaguing health conditions, but with proper identification and elimination of offending foods, many experience relief from their symptoms.

Our 144 Food Panel is a comprehensive food sensitivity testing option for patients who may have underlying sensitivities to less conspicuous antigens. Assess IgG, IgG4, or IgA antibody reactivity across a broad range of culturally-diverse foods to help identify trigger foods in these individuals.

Our super panel is a quantitative ELISA analysis of specific IgG, IgG4, and IgA antibodies to 144 common foods and spices.

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When food particles enter the bloodstream, your immune system can sometimes identify these food proteins as ‘foreign’ and produces IgG antibodies to ‘attack’ the particular food in question. 

This response is your immune system’s natural defense mechanism to ward off harmful invaders in the body which can create inflammation. This inflammation can then trigger troublesome symptoms, which may persist if they are neglected.

Suffering from IBS, headaches, bloating, tiredness? These are often signs of a food sensitivity or a food intolerance affecting your daily life. The YorkTest Premium Food Sensitivity Test analyzes IgG reactions to over 200 food and drink ingredients.

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88 Food Antigen IgE

IgE (immunoglobulin E) allergies are the immediate responses to a foreign substance that has entered the body via food or inhalation. IgE allergies can cause very serious symptoms like difficulty in breathing, swelling, and hives. In more serious cases, IgE reactions can lead to anaphylactic shock. Our test measures the blood level of IgE, one of the five subclasses of antibodies. Antibodies are proteins made by the immune system that attack antigens such as bacteria, viruses, and allergens.

They can become confused or cross-reactive and begin attacking foods instead. High titers of IgE are associated with allergic reactions, which is when the immune system overreacts to environmental antigens such as pollen, pet dander, and/or parasitic infections.

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Oxidative Stress 2.0

Oxidative Stress Analysis 2.0 is a nutritional test used to evaluate the body’s oxidative stress status. Normal human metabolism produces highly reactive molecules known as free radicals, typically controlled by antioxidants. When the production of free radicals becomes excessive, the antioxidant mechanisms of the cell become overwhelmed, resulting in oxidative damage. The Oxidative Stress 2.0 (Urine) uses a simple urine test to evaluate two key biomarkers of oxidative stress damage.

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DNA Oxidative Damage

This non-invasive test requires a single first morning void (FMV) urine collection. Detailed Information Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) is an excellent biomarker of oxidative stress and a risk factor for a variety of diseases, including cancer. Reactive oxygen species (ROS) are produced as a result of normal oxygen metabolism or exposure to xenobiotics. Excessive levels are associated with oxidative damage to lipids, proteins and DNA. ROS-induced damage to nuclear and mitochondrial DNA occurs readily at the guanosine bases that are removed by DNA repair mechanisms and excreted in urine.

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RBC Glutathione

Glutathione (GSH) is the most abundant and important intracellular antioxidant. GSH in erythrocytes is an indicator of intracellular GSH status, the overall health of cells and of the ability to endure toxic challenges. Low levels of GSH have been reported in cardiovascular disease, cancer, AIDS, autism, alcoholism, and debilitating neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It has also been associated with chronic retention of many potential toxic elements, chemicals and some drugs. Assessment and support of erythrocyte GSH can contribute to healthy aging and effective detoxification of toxic metals and chemicals.

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3hr SIBO

SIBO Profiles are non-invasive breath tests which capture exhaled hydrogen (H2) and methane (CH4) gases following patient ingestion of a lactulose solution to evaluate bacterial overgrowth of the
small intestine.

Clinicians have the option of a 2 or 3-hour SIBO assessment.
The 3-hour SIBO profile provides insight into gas levels over a longer period of time, and is recommended for patients with slower gastrointestinal transit or constipation.

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Essential Estrogens

Essential Estrogens™ is a targeted urinary hormone test designed to evaluate estrogen metabolism specifically. This hormone test offers clinical insight into parent estrogens, key estrogen metabolites, and relevant ratios and is useful for initial estrogen assessment as well as follow-up testing to monitor response to therapies and/or to check levels of previously abnormal results.

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The DUTCH Plus® takes hormone testing to a whole new level. In addition to sex hormones and their metabolites, the DUTCH CompleteTM looks at the overall diurnal pattern of free cortisol, and the total and distribution of cortisol metabolites. The DUTCH Plus® adds the Cortisol Awakening Response (CAR) to bring another important piece of the HPA-axis into focus.

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Comprehensive Female Profile II

This profile includes both saliva and dried blood spot tests, and provides a broad assessment of possible hormonal imbalances because they assess sex, adrenal, and thyroid hormone levels. These three hormone systems work in harmony, and an imbalance in one system affects the balance of the others as well. Comprehensive testing allows the health care provider to determine the appropriate treatment to restore balance and achieve overall wellness. The Comprehensive Female Profile II tests only the diurnal cortisol in saliva, while the sex and thyroid hormones are all tested using a dried blood spot specimen. This allows physicians to assess baseline levels before hormone replacement therapy and is ideal for monitoring HRT dosing. A full assessment of thyroid health, including screening for hypo or hyperthyroidism, determining Free T4 levels as well as Free T3 levels, testing for autoimmune thyroid disease, and monitoring thyroid replacement dosage is also included.

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Comprehensive Plus Salivary Hormone Panel

The Comprehensive Plus Panel expands on the Comprehensive Hormone Panel and includes estrone (E1) and estriol (E3) plus the Estrogen Quotient. The Estrogen Quotient (EQ) is a simple ratio of the cancer protective E3 to the proliferative estrogens E1 and E2. The EQ provides an assessment of breast cancer risk, with a lower number (<1.0) indicating increased risk, and a higher number (>1.0) signifying a lower risk. For maximum protection, an optimal EQ is >1.5.

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The Organix® Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body’s cellular metabolic processes. Additionally, children’s reference ranges are designed to provide more accurate pediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes.

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Organic Acids

Vitamin deficiencies and imbalances may produce a range of health issues, including fatigue, mood changes, digestive problems, and others. Our Organic Acids Profile measures 36 organic acids to create a unique patient biochemistry profile that reflects how well the body is obtaining and utilizing nutrients. A customized diet and lifestyle plan can then be established to address to specific nutritional needs.

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Adrenal Stress Profile

This profile tests the adrenal hormones DHEA-S and diurnal cortisol. When individuals experience continuous stress, not only from emotional stressors (e.g., marital, financial, and occupational) but also from physical stressors (e.g., sleep deprivation, caffeine consumption, pain, extreme exercise), it can lead to changes in adrenal hormone levels, related to disorders ranging from anxiety to infertility.

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Adrenocortex Stress Profile

The Adrenocortex Stress Profile (ASP) provides an assessment of the Hypothalamic-Pituitary-Adrenal (HPA) axis using carefully timed salivary samples of the hormones cortisol and DHEA. Salivary testing is an easy, non-invasive option to measure unbound, biologically active parent hormone levels. 

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Adrenal Function Panel

This profile provides a comprehensive view of adrenal function and includes 4 cortisol levels timed throughout the day as well as DHEA. Symptoms that would indicate ordering this profile include:

  • Fatigue
  • Nervousness
  • Weakness
  • Sugar cravings
  • Insomnia
  • Dizzy spells
  • Headaches
  • Decreased stamina
  • Irritability
  • Fibromyalgia
  • Anxiety/Depression

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DUTCH Adrenal

The DUTCH Adrenal provides free cortisol patterns that parallel saliva with the addition of metabolite measurements for an improved marker for total cortisol production. This test is run on LC-MS/MS: the most accurate way to test cortisol and metabolites!

This kit includes:

  • Easy directions and filter paper collection strips
  • Requisition form for patient information, pertinent supplements, medications, hormone replacement, and a health questionnaire
  • Sealable return mailer (Domestic Only)

The results include:

  • Daily free cortisol pattern (4)
  • Daily free cortisone pattern (4)
  • Cortisol metabolites (a-THF, b-THF)
  • Cortisone metabolites (b-THE)
  • DHEAst
  • Graphical representation of results
  • Provider notes with specific additional information created specifically for the patient

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Comprehensive Toxic and Essential Elements

We are all exposed to different amounts of essential and toxic elements depending on where we live, our diet and supplementation routine, and the environmental pollution of the air we breathe. Essential elements are only conducive to optimal health when they are within optimal ranges – levels that are too low or too high can have detrimental effects on health – and exposure to toxic heavy metals has multiple adverse health effects. The Comprehensive Toxic and Essential Elements Profile allows a complete assessment of the most important elements implicated in health-related effects, as it includes a measure of both short and long term exposure to all 4 of the most toxic environmental heavy metals, as well as highlighting nutritional element deficiencies earlier than a typical serum test. The Comprehensive Toxic & Essential Elements Profile assesses an individual’s levels of the essential nutrients iodine, selenium, zinc, copper, magnesium, lithium, and bromine, and their exposure to the toxic elements arsenic, cadmium, and mercury.

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Urine Toxic and Essential Elements

Urine Elements are traditionally used to evaluate exposure to potentially toxic elements and wasting of nutrient elements. Additionally, the comparison of urine element concentrations before and after administration of a chelator can be used to estimate net retention of potentially toxic elements. Subsequent urine element analyses, also following the administration of a chelator, are useful for monitoring the efficacy of metal detoxification therapy. Results are expressed per 24 hours or creatinine corrected to account for urine dilution effects.

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Mercury Tri-Test and Blood Metals Panel

Quicksilver Scientific is a CLIA certified laboratory offering mercury speciation and blood metal testing for human health. We use state-of-the-art testing technology, including patented mercury speciation technology, to give the most accurate and reliable metal testing availability today. The Mercury Tri-Test is the only clinical testing suite that utilize blood, hair, and urine to measure both exposure and excretion rate. The Blood Metals Panel screens a broad range of nutrient and toxic metals to show elevated exposures to toxic metals or imbalances of nutrient metals in the whole blood.

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Immune Response Panel

The COVID-19 Immune Response Panel measures both nucleocapsid (N-protein) and S-RBD antibodies. N-protein antibodies do not rise in response to COVID-19 S-RBD vaccinations. The combined serum IgM/IgG tests measure the body’s response to COVID-19 nucleocapsid (N) and spike protein receptor-binding domain (S-RBD) exposure. The N and S-RBD antibodies’ combination assay has a > 99% positive and negative predictive value 15 days after COVID-19 exposure. This test does not differentiate between IgM and IgG; studies indicate that joint testing is as or more reliable than individual IgM and IgG testing in confirming COVID-19 exposure.

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SARS-CoV-2 (COVID-19) Diagnostic Salivary PCR Test

This easy at-home salivary test can be used to diagnose the presence of the SARS-CoV-2 virus.

*This is a pre-paid test. You will be charged at the time you place your order.
** Please note that shipping charges will apply.

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Vaccine Response Panel

The COVID-19 Vaccine Response Screen measures only the antibody response to the S-RBD protein. Once the baseline immune response has been established, this test can be used post-vaccination to evaluate immune status. The average time for seroconversion has been estimated at 2-3 weeks. However, the strongest antibody responses will likely be seen after the second vaccine dose 6-8 weeks after the first inoculation.

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COVID-19 Quantitative IgG + IgM Antibody Panel

COVID-19 antibody testing utilizes a serum sample to identify exposure to the SARS-CoV-2 virus, regardless of symptom presentation. The COVID-19 IgG + IgM Antibody Panel evaluates IgG and IgM reactivity separately, providing individual results for each. This may be useful for determining the current stage of infection.

This test is performed on a high-precision chemiluminescent immunoassay that has received FDA authorization under emergency use authorization (EUA).

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NutrEval FMV® (First Morning Void) test identifies key nutritional deficiencies. The NutrEval FMV evaluates overall nutritional status to determine personalized supplementation needs for antioxidants, B-vitamins, minerals, essential fatty acids, amino acids, digestive support, and other select nutrients.

The NutrEval FMV is an advanced diagnostic tool to guide nutritional therapies, often augmenting and speeding recovery of complex chronic conditions. Select genomics biomarkers may be added to the profile for enhanced personalization of therapies.

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Micronutrient Test

Spectracell’s Micronutrient Test (MNT) will tell you exactly the micronutrients in which a patient is deficient. It evaluates how 31 different vitamins, minerals, amino acids, and antioxidants are working within a person’s cells. But it goes even further—The MNT will tell how well cells can withstand oxidative stress, how well cells are metabolizing carbohydrates and how adeptly cells function when launching an immune response.

Armed with this information, you can develop a targeted supplementation regimen based on the results. Your patients’ repletion plan will be unique to their personal biochemistry at this point in their life. Once cellular deficiencies are corrected, symptoms improve and patients often experience systemic benefit.

The one-size-fits-all approach to clinical nutrition is an outdated model. Find out exactly what your patients need.

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Fat Soluble Vitamins

The circulating levels of fat-soluble vitamins provide a good indication of their status throughout the body. The primary fat-soluble vitamins are involved in a vast array of protective and regulatory functions. The thoroughly intertwined and complementary actions among some of the fat-soluble vitamins are equally impressive with respect to optimization of health and disease prevention. Although overt deficiencies are rare, marginal status of specific fat-soluble vitamins may be affected by poor diets, inappropriate supplementation, smoking, excessive alcohol consumption, malabsorption, and increased demand associated with chronic conditions such as cardiovascular disease and diabetes.

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